I was just taken off Vimpat a few months ago for the second time. I had been on it before and no one checked before giving me a "new drug" I found Vimpat made me very depressed I was sane enough to know it had to be the drug and I was still having seizures. I started cleaning my house and planning on who would take my beloved service dog so I could kill myself. I knew it wasn't me so I went off the vimpat (told my Dr. as I did). I am much happier and if I have to live with the seizures I need to be able to be happy with the rest of my life.

I don't know about the Topamax & Vimpat, but I currently take 1750 mgs of Keppra twice daily & 400 mgs of Dilantin once daily, along with 50 mgs of Hydroxyzine HCL once daily to calm the side effects of anxiety and tension caused by the Keppra because my mood swings and random outburst of rage used to be ridiculous.

Keppra made me super Moody, and unable to concentrate.

Inability to concentrate sounds like Topamax, and if you're having memory issues, that one is a culprit, too. But a lot of meds will do those things...considering what we need them for! That's the only one you've listed that I'm experienced with, and I switched to its extended release version, Trokendi XR. It's once a day, and I've taken it at night; it doesn't seem as bad, but the same side effects are there. I'm slowly going off it, having added another Zonegran to the ones I'm taking along with my VNS. We had considered either Keppra, Vimpat, or Lamictal as another med, and decided not to do any of them. I hope someone can help you with the other two.

I am on Keppra and Lamictal. When I first went on to Keppra I was so depressed that I genuinely didn't think I'd experience happiness again. Once my dose was settled (I am on 1,000mg twice daily of Keppra) I didn't feel as bad but I was numb and didn't really ever feel happy or any emotion at all. I went to CBT (a form of psychotherapy) and it helped me so much. I recommend giving it a go, it'll help your mood, motivation etc.