It's dif per person, but I have some come at random, with my condition, they are more stable than before and I am ok with that, not complaining, I had it 51 and half years of my life, it goes with the territory, I don't quit no matter what and I am a Catholic christian mix and my religion and religious practices I have and do in my life are the best medicine ever and stand firm always doing, I am not perfect and do sin but that is my answer here! No matter what,!!!